Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physiological needs and pharmacology off curcumin
Book ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin is the biggest component of the new purple dye from turmeric, an Indian liven that is extracted from the latest rhizome of exotic plant Curcuma longa, and that is one of the Zingiberaceae loved ones. Within this section, i talk about the pharmacological products out of curcumin and you can discuss the fresh new unit angles for these points. We up coming review the latest demonstrated and you will theluckydate frГҐgesporter prospective scientific spends from curcumin. Curcumin is well known typically while the a healing representative, however, the process off step is actually intricate. Brand new pharmacological ramifications of curcumin be seemingly the result of a beneficial synergism regarding sites from poor biochemical relations which have multiple biological aim within the interrelated signaling paths. These types of aim tend to be enzymes like cyclooxygenase, lipoxygenase and you may protein kinases, and you will transcription factors instance NF-?B, STAT and you will Nrf2. Modulation ones molecules influences downstream affectors that make the new antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you may antimicrobial activities regarding curcumin. These effects was indeed checked-out when you look at the logical examples from curcumin getting serious pain and you may inflammatory diseases, cancer, Alzheimer situation, aerobic sickness, and you can diabetic issues. The latest samples used adjustable dosage from curcuminwith more wavelengths and you can cycle, into the general end you to definitely high doses regarding curcumin in the quantity of g are required to see healing outcomes. Read more
Curcumin: Synthesis, Growing Part for the Soreness Government and Wellness Effects
Book Chapter Samples of bush-derived pharmaceuticals which have become the attract out-of continuing and you may great browse and you may advancement focus possess, up until now, come some scarce. Just after many years, the final 2 decades was basically described as good 100-flex rise in what number of scientific content had written a-year you to definitely are out of significance on usage of curcumin within the biomedicine. Read more
Framework, synthesis and biological situations out-of curcumin prodrugs
Guide ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has many possible pharmacological outcomes that will provides healing software in lots of condition states, as chatted about in more detail in the earlier part. Although not, the potential scientific efficacy from curcumin is restricted because of the its physicochemical services of bad h2o solubility and you may instability, and that end up in reasonable bioavailability. Prodrugs regarding curcumin promote a means to improve of the biopharmaceutical and you will pharmacokinetic characteristics, and may also succeed exploitation of pharmacological results of curcumin. Within part, we basic feedback brand new physicochemical and you may pharmacokinetics away from curcumin. We then identify the appearance of curcumin prodrugs with increased drinking water solubility and you may improved chemicals balance which may be translated to 100 % free curcumin on bioactivation for the vivo. We stress latest profits in this field, that have a focus on the framework, synthesis and testing off prodrugs considering promoieties in addition to amino acids, essential fatty acids, nucleic acids, dicarboxylic acids, and you will polymeric product such hyaluronic acid and polyethylene glycol. This part has got the cause for optimization of the physicochemical and you can biopharmaceutical attributes therefore the physiological issues out of curcumin prodrugs, into the mission playing with ones curcumin types during the medical applications. Read more